Is the C-Reactive Protein (CRP) test a Worthy Indicator of Inflammation?

Author: Dr. E. Maruthi Prasad Dr Maruthi Prasad, PhD, is a consultant biochemist at the Department of Biochemistry, Apollo Diagnostics Globa...

Author: Dr. E. Maruthi Prasad

Dr Maruthi Prasad, PhD, is a consultant biochemist at the Department of Biochemistry, Apollo Diagnostics Global Reference Lab, Hyderabad, India. He earned his master's in biochemistry from Sri Venkateswara University in 2009. He got his PhD in biochemistry (2016) from Sri Krishnadevaraya University, India. His research focuses on Parkinson’s disease, Alzheimer’s disease, and other inflammations. His PhD program was on therapeutic targets for myocardial infarction (MI). Dr. Prasad worked on identifying novel targets for the safe treatment of CVDs. He found that PAK1 (serine/threonine kinase) is a new therapeutic target for treating MI because its expression dropped during ISO-induced MI and was brought back to almost normal in pretreated Vitex negundo leaf ethanolic extract models (EM Prasad et al., 2017). He also worked on the phytoconstituents 5, 7-dihydroxy-6,4',-dimethoxy flavanone and 3',5-dihydroxy-6,7,4',-trimethoxyflavone. These chemicals keep PAK1's expression going or make it go up or down, which protects against MI. His previous research revealed that LOX-like 1 (LOXL1), a lysyl oxidase, is emerging evidence of its effect on malignant cancer progression. The way that LOXL1 affects the Hippo pathway and functions as a tumour suppressor to limit tumour growth, invasion, and spreading by preventing YAP from working demonstrates its function in colorectal cancer (CRC) and how it works. He also worked on the lysine reductases as acetyl-transferases in threonine acetylation to specifically modify the critical threonine cluster within the transcriptional activation domain of STAT3. The key threonine acetylation sites on STAT3 were found with the help of in vitro acetylation assays, proteins, and gene expression studies with different co-transfected cells. He published several peer-reviewed international publications in multi-discipline areas with a good citation index.

Article link: https://journalspress.com/LJMHR_Volume23/Is-the-C-Reactive-Protein-CRP-test-a-Worthy-Indicator-of-Inflammation.pdf