Disordered Breath-Brain Lateralization: At the Core of Schizophrenia Pathogenesis

  Author: Dr. Ashok Kumar Dudi Summary: This narrative review, “Disordered Breath-Brain Lateralization: At the Core of Schizophrenia Pathoge...

 Author: Dr. Ashok Kumar Dudi

Summary:

This narrative review, “Disordered Breath-Brain Lateralization: At the Core of Schizophrenia Pathogenesis”, examines schizophrenia's onset utilizing biological and behavioural dimensions and self-analysis. The 20-year-old introspective psychologist summarizes research using Google Scholar and snowball searching. Physical and mental health are directly influenced by emotional stress, which affects the respiratory system. Stress raises brain oxygen requirements, causing hypoxia, which alters neuronal processes and physiological systems. Schizophrenia causes maternal difficulties and psychopathology because of dysregulated neurotrophin signalling. The basic rest-activity cycle (BRAC) regulates human homeostasis and catecholamine levels via the asymmetrically lateralized rhythms of the central nervous system (CNS) and autonomic nervous system (ANS). A nasal cycle, an ultradian oscillation associated with the ANS, regulates autonomic, cerebral, and functional states. Genetic susceptibility may enhance schizophrenia psychopathology risk. 

Nasal airflow affects cerebral hemisphere activity, linking body and thought. Contra-lateral nostril dominance is associated with peak brain hemispheric rhythm arousal. The dominant nostril arouses the contralateral brain hemisphere via relative nostril efficacy, correlated with the sympathetic nervous system (SNS). The nasal cycle is strongly linked to the alternating lateralization of brain activity, regulating cognition and the rest and activity cycle. The ultradian nasal cycle rhythms are firmly connected to brain activity's alternating lateralization and have lateralized autonomic dominance. The nasal cycle regulates plasma catecholamine levels by coupling to the lateralized ultradian ANS-CNS rhythm, which has uncrossed ANS fibres in the CNS and body periphery. 

Psychopathological disease schizophrenia is characterized by lateralized cerebral dysfunction, which overstimulates half of the body's periphery, the CNS and ANS. Overstimulation may cause brain hypoactivity, which drains energy and disrupts brain hemisphere-nasal dominance homeostatic adaptation. A clogged right nostril may cause neuro-cell hypoxia and affect cortical stimulation. Reactive oxygen species (ROS) and Reactive nitrogen species (RNS) from mitochondrial malfunction may cause cell death and neurodegeneration. In schizophrenia, "hypo-frontality," or right prefrontal brain dysfunction, causes unpleasant symptoms and attention-cognitive difficulties. The hypo-active right cerebral hemisphere, which is more dysfunctional than normal, may cause reasoning and affect issues, atypical emotional behaviour, and persistent schizophrenia. 

Due to right hemispheric hypo-frontality, schizophrenia causes a hyperactive left cerebral hemisphere. This reduces left sub-cortex glucose metabolism and increases left temporal lobe activity. The dopaminergic system in schizophrenia is more left-hemispheric. Despite right hemisphere impairment, left hemisphere hyper-activation compensates for rational reasoning and decision-making. Another cause of schizophrenia is neurotransmitter dysregulation. Degenerative prefrontal brain alterations enhance dopamine neuron turnover and hallucinations. By limiting neurotransmitter production, hypoxia may impair brain processes and cause aberrant behaviour. Regenerating dead brain cells should be the next study topic. 

In a breakthrough narrative review, "Disordered Breath-Brain Lateralization: At the Core of Schizophrenia Pathogenesis," visionary introspective psychologist Dr. Ashok Kumar Dudi explores schizophrenia's complex beginnings. This captivating investigation of genetics, behaviour, and self-analysis results from two decades of research and contemplation. 

Dr. Dudi uses Google Scholar and snowball searching to reveal the substantial relationship between emotional stress and mental and physical health. He says stress causes physiological changes, including increased brain oxygen needs, which cause hypoxia. Hypoxia changes neuronal processes and impairs vital physiological systems, shedding light on schizophrenia's development. 

Dr Dudi emphasizes the complicated interaction between physiological and psychological elements that cause this illness, focusing on neurotrophin signalling and maternal issues. His study shows that the basic rest-activity cycle (BRAC) regulates human homeostasis and catecholamine levels through asymmetrically lateralized central and autonomic nervous system (ANS) rhythms. 

The nasal cycle is an ultradian oscillation of the autonomic nerve system that connects the body's autonomic, cerebral, and functional states. Dr. Dudi explains how genetic predisposition increases schizophrenia psychopathology risk and the fascinating relationship between nasal airflow and cerebral hemisphere activity. 

Because the dominant nostril is connected to the sympathetic nervous system, it affects the peak arousal of the brain's hemispheric rhythm. In his research, Dr. Dudi finds that the nasal cycle changes the levels of catecholamines in the blood by interacting with the lateralized ultradian ANS and central nervous system (CNS) rhythm and coordinating brain activity. 

Dr. Dudi uncovers schizophrenia's lateralized brain malfunction, revealing its mystery. Hypoactive right and hyperactive left cerebral hemispheres cause a variety of symptoms, from cognitive issues to aberrant emotional behaviour. 

This maze of studies offers promise, as Dr. Dudi's work suggests brain cell regeneration may help solve schizophrenia. This fascinating study will change our knowledge of the condition and lead to new treatments. 

Prepare to be captivated by this voyage inside the mind, where science and reflection show the route to a brighter future for schizophrenia patients. Doctor Ashok Kumar Dudi's study shows the power of inquiry and the human spirit's limitless potential. Schizophrenia Unveiled: #ResearchRevelations

Author's Biography:

Dr. Ashok Kumar Dudi

Dr. Ashok Kumar Dudi is a famous psychologist who has dedicated his career to mental health and rehabilitation. With over 20 years of expertise, he has worked to empower differently-abled people, especially those with mental conditions. As a psychologist at the National Career Service Centre for Differently Abled in Ranchi, Jharkhand, India, Dr. Dudi helps his clients find jobs, training, and self-employment. He improved his skills and showed persistent commitment to helping people with various abilities accomplish their career goals. Dr. Dudi's hard work earned him his present position. 

Excellence and tireless learning have defined Dr. Dudi's schooling. He received his Master's in Psychology from Jaipur's famous University of Rajasthan. He topped University Rajasthan College, Jaipur, in 1988–89, demonstrating his academic brilliance. At the senior secondary level, he scored top marks in four of five subjects in the Central Board of Secondary Education in New Delhi courses. His unwavering persistence and devotion propelled him to academic success. 

His tenacity and recuperation are notable elements of Dr. Dudi's life and work. About 15 years ago, he struggled with schizophrenia. This phase of his life was terrible, especially professionally. Using complementary and alternative medicines, Dr. Dudi self-healed. His miraculous recovery restored his enthusiasm for life and gave him a deep purpose. 

Dr. Dudi's deep grasp of mental health prompted him to discover a gap in our understanding of schizophrenia's complexity. The COVID-19 shutdown fueled his desire to close this gap and significantly contribute to psychology. Working from home, he researched schizophrenia's complexities. Dr. Dudi's study is a major step in fulfilling his aim of contributing to psychology. 

Finally, Dr. Ashok Kumar Dudi represents the human spirit's resilience. His incredible rise from personal struggle to professional success inspires all. His steadfast commitment to the welfare of differently-abled people and his enthusiasm for mental health research continue to benefit psychology and society.

Future Research Ambitions in Further Schizophrenia Research

As I stand on the precipice of exploring with my current research on "Disordered Breath-Brain Lateralization: At the Core of Schizophrenia Pathogenesis," I am driven by a strong desire to decipher the complexities of this complex disorder and make significant contributions to the field of psychology. Building on my previous study, I'm thrilled to describe my future research ideas, which will illuminate schizophrenia's perplexing nature and possible treatments: 

1. Neuro-Regeneration Studies: Exploring neuro-regeneration is a promising pursuit. Finding ways to regenerate damaged brain cells in schizophrenia patients may enhance cognitive performance and well-being. I will study new brain cell regeneration medicines and interventions.

2. Advanced Brain Imaging Techniques: Gaining insights into schizophrenia-related cerebral processes requires cutting-edge imaging techniques. My future study will use sophisticated neuroimaging methods like fMRI and PET to trace brain activity patterns more precisely and clearly.

3. Genetic Susceptibility and Biomarkers of Schizophrenia: This is a crucial field of research. My goal is to expand my study into genetic susceptibility factors and develop biomarkers for early diagnosis and individualized treatment strategies. 

4. Intervention and Therapeutic Approaches: I am dedicated to improving the lives of those with schizophrenia. Non-invasive interventions, cognitive-behavioural therapy, and pharmaceutical treatments suited to this disorder's brain imbalances will be developed and tested in the future. 

5. Multidisciplinary Collaboration: To address schizophrenia's complexity, I want to collaborate with specialists in neurology, genetics, psychiatry, and psychology. Interdisciplinary research may illuminate this complicated illness. 

6. Longitudinal research: Tracking schizophrenia growth and its effect on people over time via long-term research. This technique will help understand the disorder's progression and improve treatments.

7. Patient-Centered Research: Prioritizing research centered on patients with schizophrenia. Future research will focus on patients' opinions and experiences to customize therapies to their needs and preferences. 

8. Community Outreach and Education: I promote schizophrenia awareness and information dissemination outside academia. Destigmatizing the condition and supporting afflicted people and their families will be my future focus. 

My future research goals are inspired by a determination to better understand schizophrenia and develop new treatments to reduce its effect on people and society. I hope each step brings us closer to understanding schizophrenia and guiding everyone to recovery.

Article Link: https://journalspress.com/LJMHR_Volume23/Disordered-Breath-Brain-Lateralization-At-the-Core-of-Schizophrenia-Pathogenesis.pdf